Publications
DMMS.R
Sieber J, Weinheimer M, Kongable G, Riddle S, Chang YY, Flacke F. In Silico Examination of Initiation of Long-Acting Insulin Analogs Toujeo Compared to Lantus Under 3 Dosing Titration Rules in Virtual Type 2 Diabetes Subjects. J Diabetes Sci Technol. 2019 Jul 9:1932296819861586. doi: 10.1177/1932296819861586 Link
T1DMS
Meneghetti L, Susto GA, Del Favero S. Detection of Insulin Pump Malfunctioning to Improve Safety in Artificial Pancreas Using Unsupervised Algorithms. J Diabetes Sci Technol. 2019 Oct 14:1932296819881452. doi: 10.1177/1932296819881452 Link
Liu C, Vehí J, Avari P, Reddy M, Oliver N, Georgiou P, Herrero P. Long-Term Glucose Forecasting Using a Physiological Model and Deconvolution of the Continuous Glucose Monitoring Signal. Sensors (Basel). 2019 Oct 8;19(19). pii: E4338. doi: 10.3390/s19194338. Link
Camerlingo N, Vettoretti M, Del Favero S, Cappon G, Sparacino G, Facchinetti A. A Real-Time Continuous Glucose Monitoring Based Algorithm to Trigger Hypotreatments to Prevent/Mitigate Hypoglycemic Events. Diabetes Technol Ther. 2019 Jul 25. doi: 10.1089/dia.2019.0139. [Epub ahead of print] Link
Mandal S, Sutradhar A. Robust multi-objective blood glucose control in Type-1 diabetic patient. IET Syst Biol. 2019 Jun;13(3):136-146. doi: 10.1049/iet-syb.2018.5093. Link
Garcia-Tirado J, Zuluaga-Bedoya C, Breton MD Identifiability Analysis of Three Control-Oriented Models for Use in Artificial Pancreas Systems. J Diabetes Sci Technol. 2018 Sep;12(5):937-952 Link
Li K, Daniels J, Liu C, Herrero-Vinas P, Georgiou P. Convolutional Recurrent Neural Networks for Glucose Prediction. IEEE J Biomed Health Inform. 2019 Apr 1. doi: 10.1109/JBHI.2019.2908488 Link
AlMatouq AA, Laleg-Kirati TM, Novara C, Rabbone I, Vincent T. Sparse Reconstruction of Glucose Fluxes using Continuous Glucose Monitors. IEEE/ACM Trans Comput Biol Bioinform. 2019 Mar 15. doi: 10.1109/TCBB.2019.2905198. [Epub ahead of print]Link
Visentin R, Schiavon M, Giegerich C, Klabunde T, Dalla Man C, Cobelli C. Incorporating Long-Acting Insulin Glargine into the UVA/ Padova Type 1 Diabetes Simulator for In Silico Testing of MDI Therapies. IEEE Trans Biomed Eng. 2019 Feb 6. doi: 10.1109/TBME.2019.2897851. [Epub ahead of print]Link
Shi D, Dassau E, Doyle FJ 3rd. Multivariate learning framework for long-term adaptation in the artificial pancreas. Bioeng Transl Med. 2018 Nov 12;4(1):61-74. Link
Xie J, Wang Q. A Data-Driven Personalized Model of Glucose Dynamics Taking Account of the Effects of Physical Activity for Type 1 Diabetes: An In Silico Study. J Biomech Eng. 2019 Jan 1;141(1). doi: 10.1115/1.4041522. Link
Visentin R, Schiavon M, Giegerich C, Klabunde T, Man CD, Cobelli C. Long-acting Insulin in Diabetes Therapy: In Silico Clinical Trials with the UVA/Padova Type 1 Diabetes Simulator. Conf Proc IEEE Eng Med Biol Soc. 2018 Jul;2018:4905-4908. doi: 10.1109/EMBC.2018.85132 Link
Schiavon M, Acciaroli G, Vettoretti M, Giaretta A, Visentin R. A Model of Acetaminophen Pharmacokinetics and its Effect on Continuous Glucose Monitoring Sensor Measurements. Conf Proc IEEE Eng Med Biol Soc. 2018 Jul;2018:159-162. doi: 10.1109/EMBC.2018.8512257.. Link
Cappon G, Vettoretti M, Marturano F, Facchinetti A, Sparacino G. Optimal Insulin Bolus Dosing in Type 1 Diabetes Management: Neural Network Approach Exploiting CGM Sensor Information. Conf Proc IEEE Eng Med Biol Soc. 2018 Jul;2018:1-4. doi: 10.1109/EMBC.2018.8512250. Link
Feng J, Hajizadeh I, Yu X, Rashid M, Turksoy K, Samadi S, Sevil M, Hobbs N, Brandt R, Lazaro C, Maloney Z, Littlejohn E, Philipson LH, Cinar A. Multi-level Supervision and Modification of Artificial Pancreas Control System. Comput Chem Eng. 2018 Apr 6;112:57-69. doi: 10.1016/j.compchemeng.2018.02.002. Epub 2018 Feb 10. Link
Nandi S, Singh T. Glycemic Control of People with Type 1 Diabetes based on Probabilistic Constraints. IEEE J Biomed Health Inform. 2018 Sep 10. doi: 10.1109/JBHI.2018.2869365. [Epub ahead of print] Link
Garcia-Tirado J, Zuluaga-Bedoya C, Breton MD. Identifiability Analysis of Three Control-Oriented Models for Use in Artificial Pancreas Systems. J Diabetes Sci Technol. 2018 Sep;12(5):937-952. doi: 10.1177/1932296818788873. Epub 2018 Aug 10. Link
Shi D, Dassau E, Doyle Iii FJ. Adaptive Zone Model Predictive Control of Artificial Pancreas Based on Glucose- and Velocity-Dependent Control Penalties. IEEE Trans Biomed Eng. 2018 Aug 21. doi: 10.1109/TBME.2018.2866392. [Epub ahead of print] Link
Cappon G, Marturano F, Vettoretti M, Facchinetti A, Sparacino G. In Silico Assessment of Literature Insulin Bolus Calculation Methods Accounting for Glucose Rate of Change. J Diabetes Sci Technol. 2018 May 1:1932296818777524. doi: 10.1177/1932296818777524. [Epub ahead of print] Link
Bertachi A, Beneyto A, Ramkissoon CM, Vehí J. Assessment of Mitigation Methods to Reduce the Risk of Hypoglycemia for Announced Exercise in a Uni-hormonal Artificial Pancreas. Diabetes Technol Ther. 2018 Apr;20(4):285-295. doi: 10.1089/dia.2017.0392. Epub 2018 Apr 2.] Link
Torrent-Fontbona F, Lopez Ibanez B. Personalised Adaptive CBR Bolus Recommender System for Type 1 Diabetes. IEEE J Biomed Health Inform. 2018 Mar 9. doi: 10.1109/JBHI.2018.2813424. [Epub ahead of print] Link
Cappon G, Vettoretti M, Marturano F, Facchinetti A, Sparacino G. A Neural-Network-Based Approach to Personalize Insulin Bolus Calculation Using Continuous Glucose Monitoring. J Diabetes Sci Technol. 2018 Mar;12(2):265-272 Link
Visentin R, Campos-Náñez E, Schiavon M, Lv D, Vettoretti M, Breton M, Kovatchev BP, Dalla Man C, Cobelli C. The UVA/Padova Type 1 Diabetes Simulator Goes From Single Meal to Single Day. J Diabetes Sci Technol. 2018 Feb 1:1932296818757747. doi: 10.1177/1932296818757747 Link
Steil GM. Best Use of Models to Advance the Artificial Pancreas. Diabetes Technol Ther. 2018 Feb 15. doi: 10.1089/dia.2017.0420. [Epub ahead of print]] Link
Samadi S, Rashid M, Turksoy K, Feng J, Hajizadeh I, Hobbs N, Lazaro C, Sevil M, Littlejohn E, Cinar A. Automatic Detection and Estimation of Unannounced Meals for Multivariable Artificial Pancreas System. Diabetes Technol Ther. 2018 Feb 6. doi: 10.1089/dia.2017.0364. [Epub ahead of print] Link
Schiavon M, Dalla Man C, Cobelli C. Insulin Sensitivity Index-Based Optimization of Insulin to Carbohydrate Ratio: In Silico Study Shows Efficacious Protection Against Hypoglycemic Events Caused by Suboptimal Therapy. Diabetes Technol Ther. 2018 Feb;20(2):98-105. Link
MohammadRidha T, Ait-Ahmed M, Chaillous L, Krempf M, Guilhem I, Poirier JY, Moog CH. Model Free iPID Control for Glycemia Regulation of Type-1 Diabetes. IEEE Trans Biomed Eng. 2018 Jan;65(1):199-206. Link
Walsh J. Issues and Ideas in Bolus Advisor Research With Commentary on “A Methodology to Compare Insulin Dosing Algorithms in Real-Life Settings”. J Diabetes Sci Technol. 2017 Nov;11(6):1183-1186. Link
Contreras I, Oviedo S, Vettoretti M, Visentin R, Vehí J. Personalized blood glucose prediction: A hybrid approach using grammatical evolution and physiological models. PLoS One. 2017 Nov 7;12(11):e0187754. Link
Campos-Náñez E, Layne JE, Zisser HC. In Silico Modeling of Minimal Effective Insulin Doses Using the UVA/PADOVA Type 1 Diabetes Simulator. J Diabetes Sci Technol. 2017 Sep 1:1932296817735341. Link
Fortwaengler K, Campos-Náñez E, Parkin CG, Breton MD. The Financial Impact of Inaccurate Blood Glucose Monitoring Systems. J Diabetes Sci Technol. 2017 Sep 1:193229681773142. Link
Vettoretti M, Facchinetti A, Sparacino G, Cobelli C. Type 1 diabetes patient decision simulator for in silico testing safety and effectiveness of insulin treatments IEEE Trans Biomed Eng. 2017 Aug 29. doi: 10.1109/TBME.2017.2746340. Link
Herrero P, Bondia J, Adewuyi O, Pesl P, El-Sharkawy M, Reddy M, Toumazou C, Oliver N, Georgiou P. Enhancing automatic closed-loop glucose control in type 1 diabetes with an adaptive meal bolus calculator – in silico evaluation under intra-day variability. Comput Methods Programs Biomed. 2017 Jul;146:125-131. Link
Breton MD, Hinzmann R, Campos-Nañez E, Riddle S, Schoemaker M, Schmelzeisen-Redeker G. Analysis of the Accuracy and Performance of a Continuous Glucose Monitoring Sensor Prototype: An In-Silico Study Using the UVA/PADOVA Type 1 Diabetes Simulator. J Diabetes Sci Technol. 2017 May;11(3):545-552./1932296817710474. Link
Campos-Náñez E, Fortwaengler K, Breton MD. Clinical Impact of Blood Glucose Monitoring Accuracy: An In-Silico Study. J Diabetes Sci Technol. 2017 May 1:1932296817710474. doi: 10.1177/1932296817710474. Link
Chakrabarty A, Zavitsanou S, Doyle Iii F, Dassau E. Event-Triggered Model Predictive Control For Embedded Artificial Pancreas Systems. IEEE Trans Biomed Eng. 2017 May 23. doi: 10.1109/TBME.2017.2707344. Link
Xie J, Wang Q. A Variable State Dimension Approach to Meal Detection and Meal Size Estimation: In Silico Evaluation Through Basal-Bolus Insulin Therapy for Type 1 Diabetes. IEEE Trans Biomed Eng. 2017 Jun;64(6):1249-1260. Link
Viceconti M, Cobelli C, Haddad T, Himes A, Kovatchev B, Palmer M. In silico assessment of biomedical products: The conundrum of rare but not so rare events in two case studies. Proc Inst Mech Eng H. 2017 May;231(5):455-466. Link
Samadi S, Turksoy K, Hajizadeh I, Feng J, Sevil M, Cinar A. Meal Detection and Carbohydrate Estimation Using Continuous Glucose Sensor Data. IEEE J Biomed Health Inform. 2017 Mar 3. doi: 10.1109/JBHI.2017.2677953. [Epub ahead of print] Link
Toffanin C, Visentin R, Messori M, Di Palma F, Magni L, Cobelli C. Towards a Run-to-Run Adaptive Artificial Pancreas: In Silico Results. IEEE Trans Biomed Eng. 2017 Jan 11. doi: 10.1109/TBME.2017.2652062 Link
Vettoretti M, Facchinetti A, Sparacino G, Cobelli C. Predicting Insulin Treatment Scenarios with the Net Effect Method: Domain of Validity. Diabetes Technol Ther. 2016 Nov;18(11):694-704. Link
Daskalaki E, Diem P, Mougiakakou SG. Model-Free Machine Learning in Biomedicine: Feasibility Study in Type 1 Diabetes. PLoS One. 2016 Jul 21;11(7):e0158722. doi: 10.1371/journal.pone.0158722. eCollection 2016. Link
Messori M, Toffanin C, Del Favero S, De Nicolao G, Cobelli C, Magni L. Model individualization for artificial pancreas. Comput Methods Programs Biomed. 2016 Jul 5. pii: S0169-2607(15)30443-0. doi: 10.1016/j.cmpb.2016.06.006. [Epub ahead of print] Link
Visentin R, Giegerich C, Jäger R, Dahmen R, Boss A, Grant M, Dalla Man C, Cobelli C, Klabunde T. Improving Efficacy of Inhaled Technosphere Insulin (Afrezza) by Postmeal Dosing: In-silico Clinical Trial with the University of Virginia/Padova Type 1 Diabetes Simulator. Diabetes Technol Ther. 2016 Jun 22. [Epub ahead of print] Link
Visentin R, Man C, Cobelli C. One-Day Bayesian Cloning of Type 1 Diabetes Subjects: Towards a Single-Day UVA/Padova Type 1 Diabetes Simulator. IEEE Trans Biomed Eng. 2016 Feb 26. [Epub ahead of print]. Link
Visentin R, Klabunde T, Grant M, Dalla Man C, Cobelli C. Incorporation of inhaled insulin into the FDA accepted University of Virginia/Padova Type 1 Diabetes Simulator. Conf Proc IEEE Eng Med Biol Soc. 2015 Aug;2015:3250-3. doi: 10.1109/EMBC.2015.7319085. Link
Li P, Yu L, Fang Q, Lee SY. A simplification of Cobelli’s glucose-insulin model for type 1 diabetes mellitus and its FPGA implementation. Med Biol Eng Comput. 2015 Dec 30. [Epub ahead of print] Link
Colmegna P, Sanchez-Pena R, Gondhalekar R, Dassau E, Doyle F. Switched LPV Glucose Control in Type 1 Diabetes. IEEE Trans Biomed Eng. 2015 Oct 5. [Epub ahead of print] Link
Zavitsanou S, Mantalaris A, Georgiadis MC, Pistikopoulos EN. In Silico Closed-Loop Control Validation Studies for Optimal Insulin Delivery in Type 1 Diabetes. IEEE Trans Biomed Eng. 2015 Oct;62(10):2369-78. doi: 10.1109/TBME.2015.2427991. Epub 2015 Apr 29. Link
Herrero P, Pesl P, Reddy M, Oliver N, Georgiou P, Toumazou C. Advanced Insulin Bolus Advisor Based on Run-To-Run Control and Case-Based Reasoning. IEEE J Biomed Health Inform. 2015 May;19(3):1087-96. Link
Zhao C, Yu C. Rapid model identification for online subcutaneous glucose concentration prediction for new subjects with type I diabetes. Comput Methods Programs Biomed. 2015 Apr;119(1):1-8. doi: 10.1016/j.cmpb.2015.02.003. Epub 2015 Feb 16. Link
Herrero P, Pesl P, Bondia J, Reddy M, Oliver N, Georgiou P, Toumazou C. Method for automatic adjustment of an insulin bolus calculator: in silico robustness evaluation under intra-day variability. IEEE Trans Biomed Eng. 2015 May;62(5):1333-44. doi: 10.1109/TBME.2014.2387293. Epub 2015 Jan 1. Link
Hu R, Li C. An Improved PID Algorithm Based on Insulin-on-Board Estimate for Blood Glucose Control with Type 1 Diabetes. Comput Math Methods Med. 2015;2015:281589. doi: 10.1155/2015/281589. Epub 2015 Oct 5. Link
Visentin R, Dalla Man C, Kudva YC, Basu A, Cobelli C. Circadian variability of insulin sensitivity: physiological input for in silico artificial pancreas. Diabetes Technol Ther. 2015 Jan;17(1):1-7. doi: 10.1089/dia.2014.0192. Link
Colmegna P, Sanchez Pena RS, Gondhalekar R, Dassau E, Doyle Iii FJ. Reducing risks in type 1 diabetes using H∞ control. IEEE Trans Biomed Eng. 2014 Dec;61(12):2939-47. doi: 10.1109/TBME.2014.2336772. Epub 2014 Jul 9. Link
Visentin R, Dalla Man C, Kovatchev B, Cobelli C. The university of Virginia/Padova type 1 diabetes simulator matches the glucose traces of a clinical trial. Diabetes Technol Ther. 2014 Jul;16(7):428-34. doi: 10.1089/dia.2013.0377. Epub 2014 Feb 26. Link
Wang Q, Molenaar P, Harsh S, Freeman K, Xie J, Gold C, Rovine M, Ulbrecht J. Personalized State-space Modeling of Glucose Dynamics for Type 1 Diabetes Using Continuously Monitored Glucose, Insulin Dose, and Meal Intake: An Extended Kalman Filter Approach. J Diabetes Sci Technol. 2014 Mar 24;8(2):331-345. [Epub ahead of print] Link
Turksoy K, Quinn L, Littlejohn E, Cinar A. Multivariable adaptive identification and control for artificial pancreas systems. IEEE Trans Biomed Eng. 2014 Mar;61(3):883-91. doi: 10.1109/TBME.2013.2291777. [Epub ahead of print] Link
Man CD, Micheletto F, Lv D, Breton M, Kovatchev B, Cobelli C. The UVA/PADOVA Type 1 Diabetes Simulator: New Features. J Diabetes Sci Technol. 2014 Jan 1;8(1):26-34. [Epub ahead of print] Link
Abbes IB, Richard PY, Lefebvre MA, Guilhem I, Poirier JY. A closed-loop artificial pancreas using a proportional integral derivative with double phase lead controller based on a new nonlinear model of glucose metabolism. J Diabetes Sci Technol. 2013 May 1;7(3):699-707. Link
Facchinetti A, Del Favero S, Sparacino G, Cobelli C. An online failure detection method of the glucose sensor-insulin pump system: improved overnight safety of type-1 diabetic subjects. IEEE Trans Biomed Eng. 2013 Feb;60(2):406-16. doi: 10.1109/TBME.2012.2227256. Epub 2012 Nov 15. Link
Zhao C, Dassau E, Jovanovič L, Zisser HC, Doyle FJ 3rd, Seborg DE. Predicting subcutaneous glucose concentration using a latent-variable-based statistical method for type 1 diabetes mellitus. J Diabetes Sci Technol 2012; May 1; 6(3):617-33. Link
Zarkogianni K, Vazeou A, Mougiakakou SG, Prountzou A, Nikita KS. An insulin infusion advisory system based on autotuning nonlinear model-predictive control. IEEE Trans Biomed Eng. 2011 Sep;58(9):2467-77. doi: 10.1109/TBME.2011.2157823. Epub 2011 May 27. Link
Cameron F, Bequette BW, Wilson DM, Buckingham BA, Lee H, Niemeyer G. A closed-loop artificial pancreas based on risk management. J Diabetes Sci Technol 2011; Mar 1; 5(2):368-79. Link
Kovatchev B, Cobelli C, Renard E, Anderson S, Breton M, Patek S, Clarke W, Bruttomesso D, Maran A, Costa S, Avogaro A, Dalla Man C, Facchinetti A, Magni L, De Nicolao G, Place J, Farret A. Multinational study of subcutaneous model-predictive closed-loop control in type 1 diabetes mellitus: summary of the results. J Diabetes Sci Technol 2010; Nov 1; 4(6):1374-81. Link
Grosman B, Dassau E, Zisser HC, Jovanovic L, Doyle FJ 3rd. Zone model predictive control: a strategy to minimize hyper- and hypoglycemic events. J Diabetes Sci Technol 2010; Jul 1; 4(4):961-75. Link
Wang Y, Dassau E, Zisser H, Jovanovič L, Doyle FJ 3rd. Automatic bolus and adaptive basal algorithm for the artificial pancreatic β-cell. Diabetes Technol Ther 2010; Nov; 12(11):879-87. Epub 2010 Sep 30. Link
Mauseth R, Wang Y, Dassau E, Kircher R Jr, Matheson D, Zisser H, Jovanovic L, Doyle FJ 3rd. Proposed clinical application for tuning fuzzy logic controller of artificial pancreas utilizing a personalization factor. J Diabetes Sci Technol 2010; Jul 1; 4(4):913-22. Link
Kovatchev BP, Breton MD, Dalla Man C, Cobelli C. In Silico Preclinical Trials: A Proof of Concept in Closed-Loop Control of Type 1 Diabetes. J Diabetes Sci Technol 2009; 3(1): 44-45. Link
Patek SD, Bequette W, Breton M, Buckingham BA, Dassau E, Doyle FJ 3rd, Lum J, Magni L, and Zisser H. In Silico Preclinical Trials: Methodology and Engineering Guide to Closed-Loop Control in Type I Diabetes Mellitus. J Diabetes Sci Technol 2009; 3(2): 269-282. Link
Clarke W, Kovatchev B. Statistical tools to analyze continuous glucose monitor data. Diabetes Technol Ther 2009; Jun; 11 Suppl 1:S45-54. Link
Man CD, Breton MD, Cobelli C Physical activity into the meal glucose-insulin model of type 1 diabetes: in silico studies. J Diabetes Sci Technol. 2009 Jan;3(1):56-67. Link
Magni L, Raimondo DM, Man CD, Breton M, Patek S, Nicolao GD, Cobelli C, Kovatchev BP. Evaluating the efficacy of closed-loop glucose regulation via control-variability grid analysis. J Diabetes Sci Technol 2008; Jul; 2(4):630-5. Link
Breton M, Kovatchev B. Analysis, Modeling, and Simulation of the Accuracy of Continuous Glucose Sensors. J Diabetes Sci Technol 2008; 2(5): 853-862. Link
Dalla Man C, Rizza RA, Cobelli C. Meal Simulation Model of the Glucose-Insulin System. IEEE Trans Biomed Eng 2007; 54(10): 1740-1749. Link
Dalla Man C, Camilleri M, Cobelli C. A System Model of Oral Glucose Absorption: Validation on Gold Standard Data. IEEE Trans Biomed Eng 2006; 53(12): 2472-2478. Link
Sandridge LC, Baglioni AJ Jr, Kongable GL, Harthun NL. Evaluation of the effect of endovascular options on infrarenal abdominal aortic aneurysm repair. Am Surg 2006; 72(8):700-4; disc 704-6. Link
Zito D, Kongable G, Anderson M. The Impact of Intensive Insulin Protocols on the Clinical Laboratory. J Ligand Assay 2005; 28(4):202-206. Link
Kovatchev BP, Gonder-Frederick LA, Cox DJ, and Clarke WL. Evaluating the Accuracy of Continuous Glucose-Monitoring Sensors: Continuous glucose-error grid analysis illustrated by TheraSense Freestyle Navigator data. DiabetesCare 2004;27:1922-1928. Link
SAAM II
Croyal M, Tran TT, Blanchard RH, Le Bail JC, Villard EF, Poirier B, Aguesse A, Billon-Crossouard S, Ramin-Mangata S, Blanchard V, Nativel B, Chemello K, Khantalin I, Thedrez A, Janiak P, Krempf M, Boixel C, Lambert G, Guillot E. PCSK9 inhibition with alirocumab reduces lipoprotein(a) levels in nonhuman primates by lowering apolipoprotein(a) production rate. Clin Sci (Lond). 2018 May 31;132(10):1075-1083. doi: 10.1042/CS20180040. Print 2018 May 31. Link
Chen ME, Chandramouli AG, Considine RV, Hannon TS, Mather KJ Comparison of β-Cell Function Between Overweight/Obese Adults and Adolescents Across the Spectrum of Glycemia. Diabetes Care. 2018 Feb;41(2):318-325. doi: 10.2337/dc17-1373. Epub 2017 Nov 28. Link
Mason A, Engelen MP, Ivanov I, Toffolo GM, Deutz NE.A Four Compartments Compartmental Model to Assess Net Whole Body Protein Breakdown Using a Pulse of Phenylalanine and Tyrosine Stable Isotopes in Humans. Am J Physiol Endocrinol Metab. 2017 Mar 7:ajpendo.00362.2016. doi: 10.1152/ajpendo.00362.2016. Link
Zvereva A, Petoussi-Henss N, Li WB, Schlattl H, Oeh U, Zankl M, Graner FP, Hoeschen C, Nekolla SG, Parodi K, Schwaiger M.Effect of blood activity on dosimetric calculations for radiopharmaceuticals. Phys Med Biol. 2016 Nov 7;61(21):7688-7703. Link
Ferasyi TR, Barrett PH, Blache D, Martin GB.Modeling the male reproductive endocrine axis – potential role for a delay mechanism in the inhibitory action of gonadal steroids on GnRH pulse frequency. Endocrinology. 2016 Feb 24:en20151913. [Epub ahead of print] Link
Zanzonico P, Carrasquillo JA, Pandit-Taskar N, O’Donoghue JA, Humm JL, Smith-Jones P, Ruan S, Divgi C, Scott AM, Kemeny NE, Fong Y, Wong D, Scheinberg D, Ritter G, Jungbluth A, Old LJ, Larson SM.PET-based compartmental modeling of (124)I-A33 antibody: quantitative characterization of patient-specific tumor targeting in colorectal cancer. Eur J Nucl Med Mol Imaging. 2015 Oct;42(11):1700-6. doi: 10.1007/s00259-015-3061-2. Epub 2015 Jul 21. Link
Kletting P, Schimmel S, Hänscheid H, Luster M, Fernández M, Nosske D, Lassmann M, Glatting G.The NUKDOS software for treatment planning in molecular radiotherapy. Z Med Phys. 2015 Sep;25(3):264-74. doi: 10.1016/j.zemedi.2015.01.001. Epub 2015 Mar 17. Link
Desai NK, Ooi EM, Mitchell PD, Furtado J, Sacks FM.Metabolism of apolipoprotein A-II containing triglyceride rich ApoB lipoproteins in humans. Atherosclerosis. 2015 Aug;241(2):326-33. doi: 10.1016/j.atherosclerosis.2015.05.013. Epub 2015 May 19. Link
Desbrée A, Bonnard T, Blanchardon E, Petiet A, Franck D, Chauvierre C, Le Visage C. Evaluation of Functionalized Polysaccharide Microparticles Dosimetry for SPECT Imaging Based on Biodistribution Data of Rats. Mol Imaging Biol. 2015 Aug;17(4):504-11. doi: 10.1007/s11307-014-0812-6. Link
Wang X, Wang WX. Physiologically Based Pharmacokinetic Model for Inorganic and Methylmercury in a Marine Fish. Environ Sci Technol. 2015 Aug 18;49(16):10173-81. doi: 10.1021/acs.est.5b02301. Epub 2015 Aug 6. Link
Giussani A. A recycling model of the biokinetics of systemic tellurium. Int J Radiat Biol. 2014 Nov;90(11):1114-8. doi: 10.3109/09553002.2014.943850. Link
Kastl M, Giussani A, Blanchardon E, Breustedt B, Fritsch P, Hoeschen C, Lopez MA. Developing a physiologically based approach for modeling plutonium decorporation therapy with DTPA. Int J Radiat Biol. 2014 Nov;90(11):1062-7. doi: 10.3109/09553002.2014.925604. Epub 2014 Aug 11. Link
Chen EP, Tai G, Ellens H. The importance of villous physiology and morphology in mechanistic physiologically-based pharmacokinetic models. Pharm Res. 2014 Feb;31(2):305-21. doi: 10.1007/s11095-013-1161-x. Epub 2013 Aug 30. Link
Holleboom AG, Jakulj L, Franssen R, Decaris J, Vergeer M, Koetsveld J, Luchoomun J, Glass A, Hellerstein MK, Kastelein JJ, Hovingh GK, Kuivenhoven JA, Groen AK, Turner SM, Stroes ES. In vivo tissue cholesterol efflux is reduced in carriers of a mutation in APOA1. J Lipid Res. 2013 Jul;54(7):1964-71. doi: 10.1194/jlr.P028449. Epub 2013 May 6. Link
Di Nardo F, Mengoni M, Morettini M. MATLAB-implemented estimation procedure for model-based assessment of hepatic insulin degradation from standard intravenous glucose tolerance test data. Comput Methods Programs Biomed. 2013 May;110(2):215-25. doi: 10.1016/j.cmpb.2012.10.007. Epub 2012 Oct 31. Link
Turner S, Voogt J, Davidson M, Glass A, Killion S, Decaris J, Mohammed H, Minehira K, Boban D, Murphy E, Luchoomun J, Awada M, Neese R, Hellerstein M. Measurement of reverse cholesterol transport pathways in humans: in vivo rates of free cholesterol efflux, esterification, and excretion. J Am Heart Assoc. 2012 Aug;1(4):e001826. doi: 10.1161/JAHA.112.001826. Epub 2012 Aug 24. Link
Tavola F, Janzen T, Giussani A, Facchinetti D, Veronese I, Uusijärvi-Lizana H, Mattsson S, Hoeschen C, Cantone MC. Nonlinear compartmental model of 18F-choline. Nucl Med Biol. 2012 Feb; 39(2):261-8. Link
Cohen MN, Christians U, Henthorn T, Vu Tran Z, Moll V, Zuk J, Galinkin J. Pharmacokinetics of single-dose intravenous ketorolac in infants aged 2-11 months. Anesth Analg. 2011 Mar;112(3):655-60. Link
Dalla Man C, Micheletto F, Sathananthan A, Rizza RA, Vella A, Cobelli C. A model of GLP-1 action on insulin secretion in nondiabetic subjects. Am J Physiol Endocrinol Metab. 2010 Jun;298(6):E1115-21. Link
Campioni M, Toffolo G, Basu R, Rizza RA, Cobelli C. Minimal model assessment of hepatic insulin extraction during an oral test from standard insulin kinetic parameters. Am J Physiol Endocrinol Metab. 2009 Oct;297(4):E941-8. Link
Franssen R, Sankatsing RR, Hassink E, Hutten B, Ackermans MT, Brinkman K, Oesterholt R, Arenas-Pinto A, Storfer SP, Kastelein JJ, Sauerwein HP, Reiss P, Stroes ES. Nevirapine increases high-density lipoprotein cholesterol concentration by stimulation of apolipoprotein A-I production. Arterioscler Thromb Vasc Biol. 2009 Sep;29(9):1336-41. Link
Finkelstein Y, Nava-Ocampo AA, Schechter T, Grant R, St Pierre E, Goldman R, Walker S, Koren G. Discrepancies in pharmacokinetic analysis results obtained by using two standard population pharmacokinetics software programs. Fundam Clin Pharmacol. 2009 Feb;23(1):53-7. Link
Yao J, Zhou JP, Ping QN. Characteristics of nobiletin-loaded nanoemulsion and its in vivo distribution in mice. Yao Xue Xue Bao. 2007 Jun;42(6):663-8. Chinese. Link
Ribeiro CV, Eastridge ML, Firkins JL, St-Pierre NR, Palmquist DL. Kinetics of fatty acid biohydrogenation in vitro. J Dairy Sci. 2007 Mar;90(3):1405-16. Link
Ooi EM, Watts GF, Ji J, Rye KA, Johnson AG, Chan DC, Barrett PH. Plasma phospholipid transfer protein activity, a determinant of HDL kinetics in vivo. Clin Endocrinol (Oxf). 2006 Dec;65(6):752-9. Link
Chan DC, Watts GF, Nguyen MN, Barrett PH. Factorial study of the effect of n-3 fatty acid supplementation and atorvastatin on the kinetics of HDL apolipoproteins A-I and A-II in men with abdominal obesity. Am J Clin Nutr. 2006 Jul;84(1):37-43. Link
Barrett PH, Chan DC, Watts GF. Thematic review series: patient-oriented research. Design and analysis of lipoprotein tracer kinetics studies in humans. J Lipid Res. 2006 Aug;47(8):1607-19. Review. Link
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Diabetes Mgmt
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