Does your diabetes simulators include the kinetics occurring at the continuous glucose sensor level or do they only model the kinetics in the interstitial fluid?

All our simulator products are based on a meal-glucose-insulin compartmental model published by Chiara Dalla Man in 2007, titled “Meal Simulation Model of the Glucose-Insulin System.” This model accurately represents glucose kinetics at the plasma level by defining the clearance rates for each compartment.

The method of glucose measurement varies depending on the type of sensor used. For instance, a continuous glucose monitor (CGM) measures glucose in the interstitial fluid. Our model extends to include the kinetics between plasma and interstitial fluid to accurately represent glucose concentrations at the interstitial level. However, it’s important to note that while our model addresses glucose kinetics, it does not directly simulate the sensor’s characteristics. Each sensor, such as a CGM, has a dedicated model that considers its specific design and characteristics.

Additionally, we offer modeling services for devices like CGM sensors and insulin pumps. If a simulation service requires CGM reference, we can model a CGM device that aligns with specific manufacturer standards.

For more details, please contact us directly.